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Our technology

How it works

Our technology provides proprietary RNA agents with liver-targeting drug delivery vehicles to restore hemostasis by precisely modulating the endogenous expression of clotting proteins in the blood. 

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Proprietary RNA sequences are developed to target disease causing proteins specific to each disease.
Sequences are encapsulated in proprietary lipid nanoparticles (LNP) for drug delivery.
RNA-LNP therapies are administered to patients via injection.
RNA-LNPs therapies localize to the liver, modulating protein expression to correct disordered coagulation.

8

patented assets

Our diverse portfolio of targets and technologies offer a suite of novel approaches for addressing the complex drivers of coagulation. We have eight patented assets in development ranging from discovery to late preclinical phase.

Our publications

Publication
Science
February 21, 2024
Lipid nanoparticles and siRNA targeting plasminogen provide lasting inhibition of fibrinolysis in mouse and dog models of hemophilia A
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Publication
ScienceAdvances
December 1, 2023
Genetically engineered transfusable platelets using mRNA lipid nanoparticles
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Publication
Journal of Thrombosis and Haemostasis
September 15, 2022
Elimination of fibrin polymer formation or crosslinking, but not fibrinogen deficiency, is protective against diet-induced obesity and associated pathologies
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Publication
Blood
March 3, 2022
Hypofibrinogenemia with preserved hemostasis and protection from thrombosis in mice with an Fga truncation mutation
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Publication
Blood
March 3, 2022
Suppression of fibrin(ogen)-driven pathologies in disease models through controlled knockdown by lipid nanoparticle delivery of siRNA
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Publication
Nature
January 12, 2022
Aortic intimal resident macrophages are essential for maintenance of the non-thrombogenic intravascular state
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Publication
Science
December 24, 2021
Fibrin is a critical regulator of neutrophil effector function at the oral mucosal barrier
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